Journal
DEVELOPMENTAL BIOLOGY
Volume 319, Issue 1, Pages 68-77Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.04.004
Keywords
regeneration; Drosophila; imaginal discs; wingless/wnt signaling; blastema; transdetermination
Categories
Funding
- NICHD NIH HHS [T32 HD007183] Funding Source: Medline
- NIGMS NIH HHS [R01 GM058282-10, R01 GM058282-04, R01 GM058282-03, R01 GM058282, R01 GM058282-02] Funding Source: Medline
Ask authors/readers for more resources
Regeneration is a vital process to maintain and repair tissues. Despite the importance of regeneration, the genes responsible for regenerative growth remain largely unknown. In Drosophila, imaginal disc regeneration can be induced either by fragmentation and in vivo culture or in situ by ubiquitous expression of wingless (wg/wnt1). Imaginal discs, like appendages in lower vertebrates, initiate regeneration by wound healing and proliferation at the wound site, forming a regeneration blastema. Most blastema cells maintain their disc-specific identity during regeneration; a few cells however, exhibit stem-cell like properties and switch to a different fate, in a phenomenon known as transdetermination. We identified three genes, regeneration (rgn), augmenter of liver regeneration (air) and Matrix metalloproteinase-1 (Mmp1) expressed. specifically in blastema cells during disc regeneration. Mutations in these genes affect both fragmentation- and wg-induced regeneration by either delaying, reducing or positioning the regeneration blastema. In addition to the modifications of blastema homeostasis, mutations in the three genes alter the rate of regeneration-induced transdetermination. We propose that these genes function in regenerative proliferation, growth and regulate cellular plasticity. Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available