Journal
DEVELOPMENTAL BIOLOGY
Volume 317, Issue 2, Pages 614-619Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.03.013
Keywords
tetraploid; heart development; transcription factors; GATA4; GATA6
Categories
Funding
- NIDDK NIH HHS [R01 DK066226-01, F32 DK067808-01, R01 DK066226-05, R01 DK055743, R01 DK066226-02, R01 DK055743-06A1, F32 DK067808-02, R01 DK066226-03, R01 DK066226-04, R01 DK066226, R01 DK055743-08, F32 DK067808-03, R01 DK055743-07, F32 DK067808] Funding Source: Medline
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Despite significant advances in identifying signaling molecules that induce cardiogenesis in mammals, the transcription factors that control the onset of cardiac myocyte gene expression have remained elusive. Candidates include the zinc finger transcription factors GATA binding proteins 4 and 6 (GATA4, GATA6). The individual loss of either protein in mice results in lethality prior to the onset of heart development due to defects in the extra-embryonic endoderm; however, when this extra-embryonic deficiency is circumvented using tetraploid embryo complementation, cardiac myrocyte differentiation initiates normally. Here we show that these factors have redundant roles in controlling the onset of cardiac myocyte differentiation. As a Gata4(-/-)Gata6(-/-) embryos completely lack hearts, although second heart field Progenitor cells are still generated. Our data support a model whereby GATA4 or GATA6 are essential for expression of the network of transcription factors that regulate the onset of cardiac myocyte gene expression during mammalian development. (C) 2008 Elsevier Inc. All Fights reserved.
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