Journal
DEVELOPMENTAL BIOLOGY
Volume 319, Issue 2, Pages 171-178Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.04.031
Keywords
nitric oxide; C-type natriuretic peptide; cGMP; cGMP-dependent kinase; cartilage; endochondralbone; MAPK pathways
Categories
Funding
- NIDCR NIH HHS [5K08DE017426, K08 DE017426-02, K08 DE017426-01A1, K08 DE017426] Funding Source: Medline
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Coordinated proliferation and differentiation of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. Recent data demonstrate important roles for nitric oxide (NO) and C-type natriuretic peptide (CNP) in the regulation of cartilage development. Both NO and CNP stimulate the synthesis of cGMP and thus the activation of common downstream pathways. One of these downstream mediators, cGMP-dependent kinase II (cGKII), has itself been shown to be essential for normal endochondral bone formation. This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development. (c) 2008 Elsevier Inc. All rights reserved.
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