Journal
DEVELOPMENTAL BIOLOGY
Volume 323, Issue 2, Pages 197-206Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2008.08.021
Keywords
Drosophila; Germ line; Oogenesis; Mitosis; Sister chromatid cohesion; Separation anxiety
Categories
Funding
- Marie Curie International Reintegration [029165]
- Fundacao para a Ciencia e Tecnologia [PPCDT/DG/BIA/82013/2006, PTDC/BIA-BCM/69256/2006, SFRH/BD/28767/2006]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/28767/2006, PTDC/BIA-BCM/69256/2006, PPCDT/DG/BIA/82013/2006] Funding Source: FCT
Ask authors/readers for more resources
During mitosis different types of cells can have differential requirements for chromosome segregation. We isolated two new alleles of the separation anxiety gene (sun). san was previously described in both Drosophila and in humans to be required for centromeric sister chromatid cohesion (Hou et al., 2007; Williams et al., 2003). Our work confirms and expands the observation that san is required in vivo for normal mitosis of different types of somatic cells. In addition, we suggest that son is also important for the correct resolution of chromosomes, implying a more general function of this acetyltransferase. Surprisingly, during oogenesis we cannot detect mitotic defects in germ line cells mutant for san. We hypothesize the female germ line stem cells have differential requirements for mitotic sister chromatid cohesion. (C) 2008 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available