Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 43, Issue 2, Pages 174-183Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.07.019
Keywords
Betanodavirus; Immunity; Marine fish
Categories
Funding
- National Science Council [NSC97-2313-B-006-001-MY3, NSC100-2313-B-006-002-MY3, NSC101-2321-B-006-015, NSC102-2321-B-006-016]
- Headquarters of University Advancement at the National Cheng Kung University
- Ministry of Education, Taiwan
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Betanodaviruses cause viral nervous necrosis in numerous fish species, but some species are resistant to infection by these viruses. It is essential to fully characterize the immune responses that underlie this protective response. Complete characterization of the immune responses against nodaviruses may allow the development of methods that stimulate fish immunity and of an effective betanodavirus vaccine. Such strategies could include stimulation of specific immune system responses or blockage of factors that decrease the immune response. The innate immune system clearly provides a front-line defense, and this includes the production of interferons and other cytokines. Interferons that are released inside infected cells and that suppress viral replication may be the most ancient form of innate immunity. This review focuses on the immune responses of fish to betanodavirus infection. (C) 2013 Elsevier Ltd. All rights reserved.
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