Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 42, Issue 1, Pages 3-15Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.08.018
Keywords
Innate immunity; Pattern recognition receptors; Toll-like receptors; Antimicrobial peptides; IMD pathway
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The functional analysis of genes from the model organism Drosophila melanogaster has provided invaluable information for many cellular and developmental or physiological processes, including immunity. The best-understood aspect of Drosophila immunity is the inducible humoral response, first recognized in 1972. This pioneering work led to a remarkable series of findings over the next 30 years, ranging from the identification and characterization of the antimicrobial peptides produced, to the deciphering of the signalling pathways activating the genes that encode them and, ultimately, to the discovery of the receptors sensing infection. These studies on an insect model coincided with a revival of the field of innate immunity, and had an unanticipated impact on the biomedical field. (C) 2013 Elsevier Ltd. All rights reserved.
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