Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 43, Issue 2, Pages 151-159Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.08.015
Keywords
Cyprinid herpesvirus 3; Immune response; Immune evasion; Immunogenetics; Common carp
Categories
Funding
- World Class University Program [R32-10253]
- Ministry of Education, Science and Technology, South Korea
- European Union [PITN-GA-2008-214505]
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Viruses from the family Alloherpesviridae form an aquatic clade of herpesviruses infecting fish and amphibia. Diseases caused by these herpesviruses are of increasing importance because of the high morbidity and mortality associated with the infection, and the difficulties in diagnosing latently infected carriers. Cyprinid herpesvirus 3 (CyHV-3) induces a severe disease and mortality in common carp and thus greatly affects carp aquaculture and trade. This review summarises advancements in the understanding of the infection process and the current knowledge on immune responses of carp to CyHV-3. A focus is laid on host genetics and immunity responsible for resistance/survival from the disease and on the viral mechanisms accountable for evasion of carp immune responses. As current knowledge of immune responses to CyHV-3 is still limited, perspectives for future studies are outlined. Analysing CyHV-3 fish-host interactions will be useful and thought-provoking for a basic understanding of fish immune responses. (C) 2013 Elsevier Ltd. All rights reserved.
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