Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 43, Issue 2, Pages 197-204Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.07.014
Keywords
Cytotoxic T cells; Vaccination; Teleost; Virus
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Funding
- Faculty of Agriculture, Kyushu University
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Cytotoxic T-cells (CTLs) play a pivotal role in eliminating viruses in mammalian adaptive immune system. Many recent studies on T-cell immunity of fish have suggested that teleost CTLs are also important for antiviral immunity. Cellular functional studies using clonal ginbuan crucian carp and rainbow trout have provided in vivo and in vitro evidence that in many respects, virus-specific CTLs of fish have functions similar to those of mammalian CTLs. In addition, mRNA expression profiles of CTL-related molecules, such as CD8, TCR and MHC class I, have shown that in a wide range of fish species, CTLs are involved in antiviral adaptive immunity. These findings are a basis to formulate possible vaccination strategies to trigger effective antiviral CTL responses in teleost fish. This review describes recent advances in our understanding of antiviral CTL functions in teleost fish and discusses vaccination strategies for efficiently inducing CTL activities. (C) 2013 Elsevier Ltd. All rights reserved.
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