Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 42, Issue 1, Pages 111-123Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.06.001
Keywords
Drosophila immunity; Natural pathogens; Coevolution
Categories
Funding
- National Institutes of Health [R01 AI081879]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI081879] Funding Source: NIH RePORTER
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Immune responses against opportunistic pathogens have been extensively studied in Drosophila, leading to a detailed map of the genetics behind innate immunity networks including the Toll, Imd, Jak-Stat, and JNK pathways. However, immune mechanisms of other organisms, such as plants, have primarily been investigated using natural pathogens. It was the use of natural pathogens in plant research that revealed the plant R-Avr system, a specialized immune response derived from antagonistic coevolution between plant immune proteins and their natural pathogens' virulence proteins. Thus, we recommend that researchers begin to use natural Drosophila pathogens to identify novel immune strategies that may have arisen through antagonistic coevolution with common natural pathogens. In this review, we address the benefits of using natural pathogens in research, describe the known natural pathogens of Drosophila, and discuss the future prospects for research on natural pathogens of Drosophila. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
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