Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 41, Issue 3, Pages 316-323Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.04.009
Keywords
TLR; Chicken; Innate immunity; Ligand specificity; Evolution; Infection
Categories
Funding
- Dutch Ministry of Economics, Welfare and Innovation
- Danish Agency for Science, Technology and Innovation [09067131]
- European Union [244547]
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Toll-like receptors (TLRs) are a major class of innate immune pattern recognition receptors that have a key role in immune homeostasis and the defense against infections. The research explosion that followed the discovery of TLRs more than a decade ago has boosted fundamental knowledge on the function of the immune system and the resistance against disease, providing a rational for clinical modulation of the immune response. In addition, the conserved nature of the ancient TLR system throughout the animal kingdom has enabled a comparative biology approach to understand the evolution, structural architecture, and function of TLRs. In the present review we focus on TLR biology in the avian species, and, especially, on the unique functional properties of the chicken TLR repertoire. (C) 2013 Elsevier Ltd. All rights reserved.
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