Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 40, Issue 3-4, Pages 248-257Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2013.02.005
Keywords
Chicken; E. coli; Leukocytes; Antibody; Costs
Categories
Funding
- USDA [1013]
- NSF, IRCEB [0212587]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0212587] Funding Source: National Science Foundation
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The immune response is thought to be costly and deters from growth and reproduction, but the magnitude and sources of these costs are unknown. Thus, we quantified the changes in mass of leukocytes (CD4(+) and CD8(+) T cells, Bu1(+) IgM(+) and Bu1+ IgG(+) B cells, monocytes/macrophages, heterophils and thrombocytes) and protective plasma proteins in systemic (non-mucosal) components of adult chickens injected intravenously with dead Escherichia coli. During the first day after E. coli injection most types of blood leukocytes decreased and alpha-1-acid glycoprotein increased. Specific IgM, specific IgY, total IgM, Bu1(+) lymphocytes in the spleen and bone marrow and thymic CD8(+) lymphocytes increased at 5 d post-injection. Quantitatively, the increases in the weight of cells and antibodies due to E. coli were dwarfed by the increase in the weight of the liver and acute, phase proteins. Thus the acute phase response was markedly more costly than the subsequent adaptive response. The weight of the cells and proteins of the systemic immune system prior to challenge was 0.14% of body weight. Following E. coli injection, the additional weight of the immune components and the hypertrophy of the liver resulted in a 3.6-fold increase in weight which is equivalent to 18.5% of a large egg. (C) 2013 Elsevier Ltd. All rights reserved.
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