Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 36, Issue 2, Pages 390-399Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2011.08.003
Keywords
Mytilus galloprovincialis; Innate immunity; Antimicrobial peptides; Big defensin; Mytimacin
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Funding
- Regione Friuli Venezia Giulia, Direzione Centrale Risorse Agricole, Naturali, Forestali e Montagna [prot. RAF/9/7.15/47174]
- [FP7-KBBE-2010-4-266157 (Bivalife)]
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Antimicrobial peptides (AMPs) play a fundamental role in the innate immunity of invertebrates, preventing the invasion of potential pathogens. Mussels can express a surprising abundance of cysteine-rich AMPs pertaining to the defensin, myticin, mytilin and mytimycin families, particularly in the circulating hemocytes. Based on deep RNA sequencing of Mytilus galloprovincialis, we describe the identification, molecular diversity and constitutive expression in different tissues of five novel transcripts pertaining to the macin family (named mytimacins) and eight novel transcripts pertaining to the big defensins family (named MgBDs). The predicted antimicrobial peptides exhibit a N-terminal signal peptide, a positive net charge and a high content in cysteines, allegedly organized in intra-molecular disulfide bridges. Mytimacins and big defensins therefore represent two novel AMP families of M. galloprovincialis which extend the repertoire of cysteine-rich AMPs in this bivalve mollusk. (C) 2011 Elsevier Ltd. All rights reserved.
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