Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 37, Issue 2, Pages 306-312Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2012.04.003
Keywords
Mucosal immunity; Cytokines; Lymphoid organs
Categories
Funding
- National Institutes of Health [AI063426, AI073689]
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Mucosa! epithelium M cells are dispersed across Peyer's patch follicle associated epithelium (PPFAE) with minimal clustering. Since Notch signaling can influence patterning in epithelia, we examined its influence on PPFAE M cell distribution. Conditional deletion of Notch1 in intestinal epithelium increased PPFAE M cells and also increased M cell clustering, implying a role for Notch in both M cell numbers and lateral inhibition. By contrast, conditional deletion of the ligand Jagged1 also increased M cell clustering, but with a paradoxical decrease in M cell density. In vitro, inhibition of Notch signaling reduced expression of an M cell associated gene CD137, consistent with cis-promoting effects on M cell development. Thus, Jagged] may have a cis-promoting role in committed M cells, but a trans-inhibitory effect on neighboring cells. In sum, Jagged1-Notch signaling may edit the pattern of M cells across the PPFAE, which may help optimize mucosal immune surveillance. (C) 2012 Elsevier Ltd. All rights reserved.
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