Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 35, Issue 12, Pages 1376-1387Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2011.07.001
Keywords
Interferon; Interferon receptor; Teleost fish; Antiviral defence; Evolution
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/C506021/1] Funding Source: Medline
- Biotechnology and Biological Sciences Research Council [BB/C506021/1] Funding Source: researchfish
Ask authors/readers for more resources
Interferons (IFNs) are the hallmark of the vertebrate antiviral system. Two of the three IFN families identified in higher vertebrates are now known to be important for antiviral defence in teleost fish. Based on the cysteine patterns, the fish type I IFN family can be divided into two subfamilies, which possibly interact with distinct receptors for signalling. The fish type II IFN family consists of two members. IFN-gamma with similar functions to mammalian IFN-gamma and a teleost specific IFN-gamma related (IFN-gamma rel) molecule whose functions are not fully elucidated. These two type II IFNs also appear to bind to distinct receptors to exert their functions. It has become clear that fish IFN responses are mediated by the host pattern recognition receptors and an array of transcription factors including the IFN regulatory factors, the Jak/Stat proteins and the suppressor of cytokine signalling (SOCS) molecules. (C) 2011 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available