Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 33, Issue 6, Pages 789-800Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2009.01.005
Keywords
Pattern recognition receptors; Bombyx mori; Innate immunity; Insect; The silkworm genome database; Hemolymph
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [20651031]
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C-type lectins can act as pattern recognition receptors (PRRs) in innate immunity. Previously, we identified two C-type lectins from silkworm (Bombyx mori), BmLBP and BmMBP, as PRRs. In the present study, we identified three homologs of these lectins by searching the silkworm genome database. These novel B. man low-expression lectins were designated BmLEL-1, BmLEL-2, and BmLEL-3. Although Western-blot analysis failed to detect BmLEL-1, -2, or -3 in plasma, affinity precipitation of larval plasma with various microorganisms revealed that BmLEL-1 and -2 bind to rough and smooth strains of Gram-negative bacteria, respectively. BmLEL-1, -2, and -3 were found to be expressed in testis and ovary, where BmLEL-2 expression was up-regulated after bacteria infection. These results indicate that the novel C-type lectins might play a role in the innate immunity in these tissues as PRRs. Here, we discuss the roles and members of the C-type lectins as primary PRRs in B. mori cellular immunity. (C) 2009 Elsevier Ltd. All rights reserved.
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