Journal
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume 32, Issue 7, Pages 825-836Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2007.12.003
Keywords
Mx protein; nodavirus; grouper
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Over-expression of grouper Mx negatively regulated nodavirus activity through direct interaction, likely via the binding and perturbation of the intracellular localization of nodavirus coat protein. Deletion analysis of grouper Mx indicated that the coat protein binds to the effector domain of Mx. The presence of grouper Mx in a poly [I:C] interferon system inhibited nodavirus infection, demonstrating that grouper Mx over-expression has an inhibitory effect on both coat protein and RNA-dependent RNA polymerase of nodavirus antigens, which results in reduced viral yields. We conclude that grouper Mx has a key role in cellular resistance to nodavirus infection. (c) 2008 Elsevier Ltd. All rights reserved.
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