Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 54, Issue 3, Pages 358-365Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1440-169X.2012.01334.x
Keywords
axon sorting; neural map; neuropilin-1; odorant receptor; positional information
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Funding
- JST PRESTO
- JSPS KAKENHI [23680038]
- Mitsubishi Foundation
- Nakajima Foundation
- Sumitomo Foundation
- Grants-in-Aid for Scientific Research [23680038] Funding Source: KAKEN
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Positional information is fundamental in development. Although molecular gradients are thought to represent positional information in various systems, the molecular logic used to interpret these gradients remains controversial. In the nervous system, sensory maps are formed in the brain based on gradients of axon guidance molecules. However, it remains unclear how axons find their targets based on relative, not absolute, expression levels of axon guidance receptors. No model solely based on axontarget interactions explains this point. Recent studies in the olfactory system suggested that the neural map formation requires axonaxon interactions, which is known as axon sorting. This review discusses how axonaxon and axontarget interactions interpret molecular gradients and determine the axonal projection sites in neural map formation.
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