Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 54, Issue 3, Pages 408-419Publisher
WILEY
DOI: 10.1111/j.1440-169X.2012.01347.x
Keywords
Drosophila larvae; locomotion; motor circuit; neural development; optogenetics
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [22115002, 221S0003]
- Japan Society for the Promotion of Science (JSPS) [23300114, 21700344]
- Grants-in-Aid for Scientific Research [24700395, 23300114, 21700344, 22115002] Funding Source: KAKEN
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How are functional neural circuits formed during development? Despite recent advances in our understanding of the development of individual neurons, little is known about how complex circuits are assembled to generate specific behaviors. Here, we describe the ways in which Drosophila motor circuits serve as an excellent model system to tackle this problem. We first summarize what has been learned during the past decades on the connectivity and development of component neurons, in particular motor neurons and sensory feedback neurons. We then review recent progress in our understanding of the development of the circuits as well as studies that apply optogenetics and other innovative techniques to dissect the circuit diagram. New approaches using Drosophila as a model system are now making it possible to search for developmental rules that regulate the construction of neural circuits.
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