Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 51, Issue 9, Pages 735-742Publisher
WILEY
DOI: 10.1111/j.1440-169X.2009.01141.x
Keywords
cell adhesion; cell migration; glycogen synthase kinase 3
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Glycogen synthase kinase 3 (GSK3) is one of the few master switch kinases that regulate many aspects of cell functions. Recent studies on cell polarization and migration have shown that GSK3 is also essential for proper regulation of these processes. GSK3 influences cell migration as one of the regulators of the spatiotemporally controlled dynamics of the actin cytoskeleton, microtubules, and cell-to-matrix adhesions. In this mini-review, the effects of GSK3 on these three aspects of cell migration will be discussed.
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