Journal
DEVELOPMENT GENES AND EVOLUTION
Volume 219, Issue 11-12, Pages 609-612Publisher
SPRINGER
DOI: 10.1007/s00427-009-0314-8
Keywords
Direct development; Eleutherodactylus coqui; Muscle, leg; Somite; Anuran amphibian
Funding
- National Science Foundation (US) [IOB0343403]
- National Institute of Child Health and Human Development (NIH) [1R15HD059070-01]
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In order to identify prospective limb muscle cells in a frog, we cloned Lbx1 from the direct developing frog Eleutherodactylus coqui. Like in embryos of the frog Xenopus laevis but unlike in other vertebrates, EcLbx1 is expressed in all trunk somites. Like in embryos of chick, mouse, and zebrafish, cells expressing EcLbx1 are then found in limb buds, consistent with migration of those cells from somites. EcLbx1 is also expressed in the dorsal spinal cord as in other vertebrates.
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