Journal
DEVELOPMENT
Volume 145, Issue 21, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.162552
Keywords
Adrenal gland; Autonomic nervous system; Axon dguidance; Chromaffin cell; Neural crest cell; Neuropilin
Categories
Funding
- National Health and Medical Research Council [APP106958]
- Biotechnology and Biological Sciences Research Council [BB/J00930X/1]
- BBSRC [BB/I008373/1, BB/J00930X/1] Funding Source: UKRI
Ask authors/readers for more resources
The adrenal medulla is composed of neuroendocrine chromaffin cells that secrete adrenaline into the systemic circulation to maintain physiological homeostasis and enable the autonomic stress response. How chromaffin cell precursors colonise the adrenal medulla and how they become connected to central nervous system-derived preganglionic sympathetic neurons remain largely unknown. By combining lineage tracing, gene expression studies, genetic ablation and the analysis of mouse mutants, we demonstrate that preganglionic axons direct chromaffin cell precursors into the adrenal primordia. We further show that preganglionic axons and chromaffin cell precursors require class 3 semaphorin (SEMA3) signalling through neuropilins (NRP) to target the adrenal medulla. Thus, SEMA3 proteins serve as guidance cues to control formation of the adrenal neuroendocrine system by establishing appropriate connections between preganglionic neurons and adrenal chromaffin cells that regulate the autonomic stress response.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available