Journal
DEVELOPMENT
Volume 141, Issue 10, Pages 1987-1998Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.102228
Keywords
Actin; Adhesion; Apical; Cadherin; Constriction; Myosin
Categories
Funding
- National Institutes of Health (NIH)
- American Heart Association
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Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates. In recent years, progress has been made towards understanding how the distinct cell biological processes that together drive apical constriction are coordinated. These processes include the contraction of actin-myosin networks, which generates force, and the attachment of actin networks to cell-cell junctions, which allows forces to be transmitted between cells. Different cell types regulate contractility and adhesion in unique ways, resulting in apical constriction with varying dynamics and subcellular organizations, as well as a variety of resulting tissue shape changes. Understanding both the common themes and the variations in apical constriction mechanisms promises to provide insight into the mechanics that underlie tissue morphogenesis.
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