Journal
DEVELOPMENT
Volume 141, Issue 22, Pages 4199-4205Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.101071
Keywords
GPCR; Cell migration; Chemokine; CXCL12; CXCR4
Categories
Funding
- National Institutes of Health [NS069839, HD007520]
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Chemokines are a group of small, secreted molecules that signal through G protein-coupled receptors to promote cell survival and proliferation and to provide directional guidance to migrating cells. CXCL12 is one of the most evolutionary conserved chemokines and signals through the chemokine receptor CXCR4 to guide cell migration during embryogenesis, immune cell trafficking and cancer metastasis. Here and in the accompanying poster, we provide an overview of chemokine signaling, focusing on CXCL12, and we highlight some of the different chemokine-dependent strategies used to guide migrating cells.
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