4.7 Article

Adult neurogenesis: mechanisms and functional significance

Journal

DEVELOPMENT
Volume 141, Issue 10, Pages 1983-1986

Publisher

COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.104596

Keywords

Neural stem cell; Neurogenesis; Neurons; Neuropsychiatric disease

Funding

  1. Swiss National Science Foundation (SNSF)
  2. Zurich Neuroscience Center (ZNZ)
  3. European Molecular Biology Organization (EMBO) Young Investigator program

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New neurons are generated throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, has been implicated in physiological brain function, and failing or altered neurogenesis has been associated with a number of neuropsychiatric diseases. Here, we provide an overview of the mechanisms governing the neurogenic process in the adult brain and describe how new neurons may contribute to brain function in health and disease.

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