Journal
DEVELOPMENT
Volume 141, Issue 20, Pages 3834-3841Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.102368
Keywords
Cell cycle; Embryonic development; Gap phases
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Funding
- UK Medical Research Council Programme [A252-5RG50]
- Wellcome Trust Sanger Institute
- Wellcome Trust
- Medical Research Council [MC_U117597140] Funding Source: researchfish
- MRC [MC_U117597140] Funding Source: UKRI
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The initial phases of embryonic development occur in the absence of de novo transcription and are instead controlled by maternally inherited mRNAs and proteins. During this initial period, cell cycles are synchronous and lack gap phases. Following this period of transcriptional silence, zygotic transcription begins, the maternal influence on development starts to decrease, and dramatic changes to the cell cycle take place. Here, we discuss recent work that is shedding light on the maternal to zygotic transition and the interrelated but distinct mechanisms regulating the onset of zygotic transcription and changes to the cell cycle during early embryonic development.
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