Journal
DEVELOPMENT
Volume 141, Issue 7, Pages 1427-1441Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.074666
Keywords
Cilia; Ciliogenesis; FOXJ1; Motile cilia; RFX; Transcriptional regulation
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Funding
- Swedish Research Council
- Marcus Borgstrom Foundation
- NordForsk Nordic networks
- Agency for Science, Technology and Research (A*STAR) of Singapore
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Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.
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