Journal
DEVELOPMENT
Volume 141, Issue 18, Pages 3445-3457Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.083691
Keywords
Adult stem cells; Hedgehog signaling; Homeostasis
Categories
Funding
- National Institute of Mental Health, National Cancer Institute
- National Brain Tumor Society
- Geoffrey Beene Cancer Research Center
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The hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions during development, and HH signaling continues in discrete populations of cells within many adult mammalian tissues. Growing evidence indicates that HH regulates diverse quiescent stem cell populations, but the exact roles that HH signaling plays in adult organ homeostasis and regeneration remain poorly understood. Here, we review recently identified functions of HH in modulating the behavior of tissue-specific adult stem and progenitor cells during homeostasis, regeneration and disease. We conclude that HH signaling is a key factor in the regulation of adult tissue homeostasis and repair, acting via multiple different routes to regulate distinct cellular outcomes, including maintenance of plasticity, in a context-dependent manner.
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