Journal
DEVELOPMENT
Volume 141, Issue 5, Pages 977-987Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.098392
Keywords
Mediator complex; Transcription; Cell fate; Lineage development; Disease
Categories
Funding
- Chinese Academy of Sciences (CAS)
- China Ministry of Science and Technology
- Chinese Natural Science Foundation
- China Postdoctoral Science Foundation
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Mediator is a multiprotein complex that is required for gene transcription by RNA polymerase II. Multiple subunits of the complex show specificity in relaying information from signals and transcription factors to the RNA polymerase II machinery, thus enabling control of the expression of specific genes. Recent studies have also provided novel mechanistic insights into the roles of Mediator in epigenetic regulation, transcriptional elongation, termination, mRNA processing, noncoding RNA activation and super enhancer formation. Based on these specific roles in gene regulation, Mediator has emerged as a master coordinator of development and cell lineage determination. Here, we describe the most recent advances in understanding the mechanisms of Mediator function, with an emphasis on its role during development and disease.
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