Journal
DEVELOPMENT
Volume 141, Issue 4, Pages 752-760Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.097386
Keywords
Directed differentiation; Embryonic stem cells; Gastrointestinal disease; Gut tube; Intestinal morphogenesis; Pluripotent stem cells
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Funding
- University of Michigan Center for Organogenesis
- University of Michigan Biological Sciences Scholar Program
- National Institute of Diabetes and Digestive and Kidney Diseases
- March of Dimes Basil O'Connor new investigator award
- National Institutes of Health
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With the high prevalence of gastrointestinal disorders, there is great interest in establishing in vitro models of human intestinal disease and in developing drug-screening platforms that more accurately represent the complex physiology of the intestine. We will review how recent advances in developmental and stem cell biology have made it possible to generate complex, three-dimensional, human intestinal tissues in vitro through directed differentiation of human pluripotent stem cells. These are currently being used to study human development, genetic forms of disease, intestinal pathogens, metabolic disease and cancer.
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