Journal
DEVELOPMENT
Volume 141, Issue 10, Pages 2064-2074Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.107938
Keywords
DM-GRASP; Xenopus laevis; alcam; Kidney; Pronephros
Categories
Funding
- Medical Faculty of Ulm University
- DFG [SFB497, TpA6]
Ask authors/readers for more resources
Proper development of nephrons is essential for kidney function. beta-Catenin-independent Wnt signaling through Fzd8, Inversin, Daam1, RhoA and Myosin is required for nephric tubule morphogenesis. Here, we provide a novel mechanism through which non-canonical Wnt signaling contributesto tubular development. Using Xenopus laevis as a model system, we found that the cell-adhesion molecule Alcam is required for proper nephrogenesis and functions downstream of Fzd3 during embryonic kidney development. We found alcam expression to be independent of Fzd8 or Inversin, but to be transcriptionally regulated by the beta-Catenin-independent Wnt/JNK pathway involving ATF2 and Pax2 in a direct manner. These novel findings indicate that several branches of Wnt signaling are independently required for proximal tubule development. Moreover, our data indicate that regulation of morphogenesis by non-canonical Wnt ligands also involves direct transcriptional responses in addition to the effects on a post-translational level.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available