Journal
DEVELOPMENT
Volume 140, Issue 9, Pages 1843-1856Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.087627
Keywords
Spindle; Microtubules; Oriented cell division; Polarity; Mitosis; Centrosome
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Funding
- National Institutes of Health
- Damon Runyon Cancer Research Foundation
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Orientation of the cell division axis is essential for the correct development and maintenance of tissue morphology, both for symmetric cell divisions and for the asymmetric distribution of fate determinants during, for example, stem cell divisions. Oriented cell division depends on the positioning of the mitotic spindle relative to an axis of polarity. Recent studies have illuminated an expanding list of spindle orientation regulators, and a molecular model for how cells couple cortical polarity with spindle positioning has begun to emerge. Here, we review both the well-established spindle orientation pathways and recently identified regulators, focusing on how communication between the cell cortex and the spindle is achieved, to provide a contemporary view of how positioning of the mitotic spindle occurs.
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