Journal
DEVELOPMENT
Volume 140, Issue 12, Pages 2576-2585Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.092270
Keywords
Age-related macular degeneration; Retinitis pigmentosa; Stargardt's disease; Stem cells; Clinical trials
Categories
Funding
- London Project to Cure Blindness
- Medical Research Council (MRC) UK
- California Institute of Regenerative Medicine (CIRM)
- Fight for Sight UK
- Lincy Foundation
- Macular Society
- National Institute for Health Research (NIHR) Biomedical Research Centre based at Moorfields Eye Hospital National Health Service (NHS) Foundation Trust
- University College London Institute of Ophthalmology
- MRC [G1000730, G0300288] Funding Source: UKRI
- Medical Research Council [G0300288, G1000730] Funding Source: researchfish
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Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem cells and bone marrow-derived stem cells to treat visual disorders such as age-related macular degeneration, Stargardt's disease and retinitis pigmentosa. Over a decade of analysing the developmental cues involved in retinal generation and stem cell biology, coupled with extensive surgical research, have yielded differing cellular approaches to tackle these retinopathies. Here, we review these various stem cell-based approaches for treating retinal diseases and discuss future directions and challenges for the field.
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