Journal
DEVELOPMENT
Volume 140, Issue 7, Pages 1385-1395Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.084459
Keywords
ChIP; Conserved non-coding elements; Cis regulation; Enhancer assay; Phylotypic stage
Categories
Funding
- Medical Research Council Career Development Award
- Lister Institute Research Prize
- Medical Research Council [G0700213] Funding Source: researchfish
- MRC [G0700213] Funding Source: UKRI
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It is a truth (almost) universally acknowledged that conserved non-coding genomic sequences function in the cis regulation of neighbouring genes. But is this a misconception? The literature is strewn with examples of conserved non-coding sequences being able to drive reporter expression, but the extent to which such sequences are actually used endogenously in vivo is only now being rigorously explored using unbiased genome-scale approaches. Here, we review the emerging picture, examining the extent to which conserved non-coding sequences equivalently regulate gene expression in different species, or at different developmental stages, and how genomics approaches are revealing the relationship between sequence conservation and functional use of cis-regulatory elements.
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