Journal
DEVELOPMENT
Volume 140, Issue 10, Pages 2061-2074Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.062984
Keywords
PCP; PIN; Auxin; Organiser; Polarity
Categories
Funding
- UK Biotechnology and Biological Research Council
- Wellcome Turst
- Natural Sciences and Engineering Council of Canada
- Gatsby Charitable Foundation
- Royal Society Dorothy Hodgkin Fellowship
- BBSRC [BBS/E/J/000C0646, BBS/E/J/000C0645, BB/F005997/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000C0646, BBS/E/J/000C0645, BB/F005997/1, BBS/E/J/00000152] Funding Source: researchfish
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Tissue cell polarity plays a major role in plant and animal development. We propose that a fundamental building block for tissue cell polarity is the process of intracellular partitioning, which can establish individual cell polarity in the absence of asymmetric cues. Coordination of polarities may then arise through cell-cell coupling, which can operate directly, through membrane-spanning complexes, or indirectly, through diffusible molecules. Polarity is anchored to tissues through organisers located at boundaries. We show how this intracellular partitioning-based framework can be applied to both plant and animal systems, allowing different processes to be placed in a common evolutionary and mechanistic context.
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