Journal
DEVELOPMENT
Volume 140, Issue 18, Pages 3715-3718Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.090605
Keywords
Chromatin loops; Cohesion; Cohesinopathies
Categories
Funding
- Ministerio de Economia y Competitividad
- La Caixa predoctoral fellowship
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Cohesin is a ring-shaped complex, conserved from yeast to human, that was named for its ability to mediate sister chromatid cohesion. This function is essential for chromosome segregation in both mitosis and meiosis, and also for DNA repair. In addition, more recent studies have shown that cohesin influences gene expression during development through mechanisms that likely involve DNA looping and interactions with several transcriptional regulators. Here, we provide an overview of how cohesin functions, highlighting its role both in development and in disease.
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