Journal
DEVELOPMENT
Volume 140, Issue 12, Pages 2562-2575Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.092262
Keywords
CNS rejuvenation; CNS stem cells; Disease
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Funding
- National Health and Medical Research Council of Australia
- Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute
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The growing burden of the rapidly ageing global population has reinvigorated interest in the science of ageing and rejuvenation. Among organ systems, rejuvenation of the central nervous system (CNS) is arguably the most complex and challenging of tasks owing, among other things, to its startling structural and functional complexity and its restricted capacity for repair. Thus, the prospect of meaningful rejuvenation of the CNS has seemed an impossible goal; however, advances in stem cell science are beginning to challenge this assumption. This Review outlines these advances with a focus on ageing and rejuvenation of key endogenous stem and progenitor cell compartments in the CNS. Insights gleaned from studies of model organisms, chiefly rodents, will be considered in parallel with human studies.
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