Journal
DEVELOPMENT
Volume 140, Issue 4, Pages 705-717Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.086165
Keywords
Human pluripotent stem cells; Directed differentiation; Gene targeting; High-throughput screening
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Funding
- National Institutes of Health (NIH)
- Basil O'Connor Starter Scholar Award from March of Dimes Birth Defects Foundation
- Louis V. Gerstner Jr Young Investigators Award
- Memorial Sloan-Kettering Cancer Center Society Special Projects Committee
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Developmental biology has long benefited from studies of classic model organisms. Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and human induced pluripotent stem cells, have emerged as a new model system that offers unique advantages for developmental studies. Here, we discuss how studies of hPSCs can complement classic approaches using model organisms, and how hPSCs can be used to recapitulate aspects of human embryonic development 'in a dish'. We also summarize some of the recently developed genetic tools that greatly facilitate the interrogation of gene function during hPSC differentiation. With the development of high-throughput screening technologies, hPSCs have the potential to revolutionize gene discovery in mammalian development.
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