Journal
DEVELOPMENT
Volume 140, Issue 11, Pages 2247-2251Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.091751
Keywords
Neural crest cells; Epithelium-to-mesenchyme transition; Cell migration; Chemotaxis; Contact-inhibition of locomotion; Cancer; Neurocristopathies
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Funding
- UK Medical Research Council
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- MRC [MR/J000655/1] Funding Source: UKRI
- Medical Research Council [MR/J000655/1] Funding Source: researchfish
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The neural crest (NC) is a highly migratory multipotent cell population that forms at the interface between the neuroepithelium and the prospective epidermis of a developing embryo. Following extensive migration throughout the embryo, NC cells eventually settle to differentiate into multiple cell types, ranging from neurons and glial cells of the peripheral nervous system to pigment cells, fibroblasts to smooth muscle cells, and odontoblasts to adipocytes. NC cells migrate in large numbers and their migration is regulated by multiple mechanisms, including chemotaxis, contact-inhibition of locomotion and cell sorting. Here, we provide an overview of NC formation, differentiation and migration, highlighting the molecular mechanisms governing NC migration.
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