Journal
DEVELOPMENT
Volume 139, Issue 19, Pages 3471-3486Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.071209
Keywords
Epithelial-mesenchymal transition; Gastrulation; Neural crest; Heart morphogenesis
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Funding
- Institute of Molecular and Cell Biology, A-star, Singapore
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Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that occurs during development and is essential for shaping embryos. Also implicated in cancer, this morphological transition is executed through multiple mechanisms in different contexts, and studies suggest that the molecular programs governing EMT, albeit still enigmatic, are embedded within developmental programs that regulate specification and differentiation. As we review here, knowledge garnered from studies of EMT during gastrulation, neural crest delamination and heart formation have furthered our understanding of tumor progression and metastasis.
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