Journal
DEVELOPMENT
Volume 139, Issue 21, Pages 3897-3904Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.073007
Keywords
Convergent extension; Collective cell migration; Cell intercalation; Planar cell polarity
Categories
Funding
- UK Medical Research Council (MRC)
- Royal Society
- Fonds zur Forderung der wissenschaftlichen Forschung (FWF)
- Deutsche Forschungsgemeinschaft (DFG)
- Institute of Science and Technology Austria
- MRC [G0401126] Funding Source: UKRI
- Medical Research Council [G0401126] Funding Source: researchfish
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Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing and extension. Both collective cell migration and cell intercalation are thought to drive CE and are used to different degrees in various species as they elongate their body axis. Here, we provide an overview of CE as a general strategy for body axis elongation and discuss conserved and divergent mechanisms underlying CE among different species.
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