Journal
DEVELOPMENT
Volume 139, Issue 18, Pages 3277-3299Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.063495
Keywords
Signaling; Cardiac septation; Congenital heart disease; Heart development; Transcription; Valve development
Categories
Funding
- Oak Foundation
- March of Dimes Foundation
- Lucile Packard Foundation
- National Institutes of Health (NIH)
- Children's Heart Foundation
- Office of the University of California (TRDRP)
- California Institute of Regenerative Medicine
- American Heart Association (AHA)
- Lucille P. Markey Stanford Graduate Fellowship
- Stanford Institutional Fund
Ask authors/readers for more resources
Heart malformations are common congenital defects in humans. Many congenital heart defects involve anomalies in cardiac septation or valve development, and understanding the developmental mechanisms that underlie the formation of cardiac septal and valvular tissues thus has important implications for the diagnosis, prevention and treatment of congenital heart disease. The development of heart septa and valves involves multiple types of progenitor cells that arise either within or outside the heart. Here, we review the morphogenetic events and genetic networks that regulate spatiotemporal interactions between the cells that give rise to septal and valvular tissues and hence partition the heart.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available