Journal
DEVELOPMENT
Volume 139, Issue 13, Pages 2267-2282Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.070110
Keywords
Cell fate; Chromatin; Differentiation; Prdm; SET; Transcription
Categories
Funding
- Japan Society for Promotion of Sciences (JSPS)
- RIKEN Brain Science Institute (BSI)
- RIKEN
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Members of the Prdm family are characterized by an N-terminal PR domain that is related to the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific DNA binding and protein-protein interactions. Prdm factors either act as direct histone methyltransferases or recruit a suite of histone-modifying enzymes to target promoters. In this way, they function in many developmental contexts to drive and maintain cell state transitions and to modify the activity of developmental signalling pathways. Here, we provide an overview of the structure and function of Prdm family members and discuss the roles played by these proteins in stem cells and throughout development.
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