Journal
DEVELOPMENT
Volume 139, Issue 13, Pages 2255-2266Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.073304
Keywords
Tudor domain; RNA metabolism; Chromatin; piRNA
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Funding
- Temasek Life Sciences Laboratory
- Singapore Millennium Foundation
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Tudor domain proteins function as molecular adaptors, binding methylated arginine or lysine residues on their substrates to promote physical interactions and the assembly of macromolecular complexes. Here, we discuss the emerging roles of Tudor domain proteins during development, most notably in the Piwi-interacting RNA pathway, but also in other aspects of RNA metabolism, the DNA damage response and chromatin modification.
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