Journal
DEVELOPMENT
Volume 139, Issue 16, Pages 2845-2856Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.069088
Keywords
Muscle regeneration; Pax7; Satellite cells; Skeletal muscle; Stem cells
Categories
Funding
- Muscular Dystrophy Campaign
- Medical Research Council
- Wellcome Trust
- Association Francaise Contre les Myopathies (AFM)
- OPTISTEM from the European Commission 7th Framework Programme [223098]
- BIODESIGN from the European Commission 7th Framework Programme [262948-2]
- INSERM Avenir Program
- AFM
- Association Institut de Myologie
- Agence Nationale pour la Recherche (ANR) via the labex REVIVE network
- Ligue Nationale Contre le Cancer (LNCC)
- Association pour la Recherche contre le Cancer (ARC)
- Fondation pour la Recherche Medicale
- Institut National du Cancer (INCa)
- ANR grant Epimuscle
- European Union Seventh Framework Programme for the project ENDOSTEM [241440]
- German Research Foundation (DFG)
- French-German University (UFA-DFH)
- AFM as part of the MyoGrad International Research Training Group for Myology
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Following their discovery in 1961, it was speculated that satellite cells were dormant myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this accumulated over the years, until the link between satellite cells and the myoblasts that appear during muscle regeneration was finally established. Subsequently, it was demonstrated that, when grafted, satellite cells could also self-renew, conferring on them the coveted status of 'stem cell'. The emergence of other cell types with myogenic potential, however, questioned the precise role of satellite cells. Here, we review recent recombination-based studies that have furthered our understanding of satellite cell biology. The clear consensus is that skeletal muscle does not regenerate without satellite cells, confirming their pivotal and non-redundant role.
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