Journal
DEVELOPMENT
Volume 139, Issue 7, Pages 1229-1245Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.073593
Keywords
Valvulogenesis; Hematopoiesis; Angiogenesis; Cilia; Left-right organizer; Stokes flow; Navier-Stokes equations; Cardiovascular development; Mechanodetection
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Funding
- Human Frontier Science Program
- Institut National de la Sante et de la Recherche Medicale
- Association Francaise Contre les Myopathies
- FRM
- European Community
- US National Science Foundation
- National Institutes of Health [R01AI052348]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0932607] Funding Source: National Science Foundation
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Throughout morphogenesis, cells experience intracellular tensile and contractile forces on microscopic scales. Cells also experience extracellular forces, such as static forces mediated by the extracellular matrix and forces resulting from microscopic fluid flow. Although the biological ramifications of static forces have received much attention, little is known about the roles of fluid flows and forces during embryogenesis. Here, we focus on the microfluidic forces generated by cilia-driven fluid flow and heart-driven hemodynamics, as well as on the signaling pathways involved in flow sensing. We discuss recent studies that describe the functions and the biomechanical features of these fluid flows. These insights suggest that biological flow determines many aspects of cell behavior and identity through a specific set of physical stimuli and signaling pathways.
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