Journal
DEVELOPMENT
Volume 139, Issue 19, Pages 3583-3589Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.081778
Keywords
Spermiogenesis; Mouse model; Acrosome
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [20062008, 24770210, 23500492, 24700430, 21112006, 20670006] Funding Source: KAKEN
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SPACA1 is a membrane protein that localizes in the equatorial segment of spermatozoa in mammals and is reported to function in sperm-egg fusion. We produced a Spaca1 gene-disrupted mouse line and found that the male mice were infertile. The cause of this sterility was abnormal shaping of the sperm head reminiscent of globozoospermia in humans. Disruption of Spaca1 led to the disappearance of the nuclear plate, a dense lining of the nuclear envelope facing the inner acrosomal membrane. This coincided with the failure of acrosomal expansion during spermiogenesis and resulted in the degeneration and disappearance of the acrosome in mature spermatozoa. Thus, these findings clarify part of the cascade leading to globozoospermia.
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