Journal
DEVELOPMENT
Volume 140, Issue 1, Pages 3-12Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.080531
Keywords
Cancer; Endocycle; Endomitosis; Endoreplication; Genome instability
Categories
Funding
- Whitehead Foundation
- Pew Charitable Trust
- National Institutes of Health
Ask authors/readers for more resources
Polyploid cells have genomes that contain multiples of the typical diploid chromosome number and are found in many different organisms. Studies in a variety of animal and plant developmental systems have revealed evolutionarily conserved mechanisms that control the generation of polyploidy and have recently begun to provide clues to its physiological function. These studies demonstrate that cellular polyploidy plays important roles during normal development and also contributes to human disease, particularly cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available