Journal
DEVELOPMENT
Volume 139, Issue 13, Pages 2447-2451Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.075978
Keywords
Parkinson's disease; Dopamine neurons; Nurr1; Neuronal maturation; Doxycycline inducible expression system
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Funding
- Future-based Technology Development Program [2011-0019404]
- Medical Research Center [2011-0028261]
- Basic Science Research Program [2012-0002653]
- National Research Foundation of Korea
- Ministry of Education, Science and Technology [KRF-2008-355-C00018]
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Neural stem/progenitor cell (NSC/NPC) cultures can be a source of dopamine (DA) neurons for experimental and transplantation purposes. Nurr1, a steroid receptor transcription factor, can overcome the limitations associated with differentiation of cultured NPCs into DA neurons. However, forced Nurr1 expression in NPC cultures generates non-neuronal and/or immature DA cells. We show here that the Nurr1 level and period of expression crucially affect the differentiation and maturation of Nurr1-induced DA neurons. Mature DA neurons were generated by manipulating Nurr1 expression patterns to resemble those in the developing midbrain.
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