Journal
DEVELOPMENT
Volume 138, Issue 9, Pages 1653-1661Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.056234
Keywords
siRNA; MicroRNA; Stem cells; Oocyte; Embryonic development
Categories
Funding
- National Institutes of Health
- California Institute of Regenerative Medicine (CIRM)
- American Health Assistance Foundation
- Pew Charitable Trust
- NICHD/NIH
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Small non-coding RNAs, including microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), play essential roles in mammalian development. The function and timing of expression of these three classes of small RNAs differ greatly. piRNAs are expressed and play a crucial role during male gametogenesis, whereas endo-siRNAs are essential for oocyte meiosis. By contrast, miRNAs are ubiquitously expressed in somatic tissues and function throughout post-implantation development. Surprisingly, however, miRNAs are non-essential during preimplantation embryonic development and their function is suppressed during oocyte meiosis. Here, we review the roles of small non-coding RNAs during the early stages of mammalian development, from gamete maturation through to gastrulation.
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