Journal
DEVELOPMENT
Volume 138, Issue 6, Pages 1017-1031Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.040998
Keywords
AGM region; Yolk sac; Placenta; dHSC; Pre-dHSC
Categories
Funding
- Leukaemia and Lymphoma Research
- MRC
- BBSRC
- Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/H008780/1, BB/D01347X/1] Funding Source: researchfish
- Medical Research Council [G0700711B, G0900962, G0500950] Funding Source: researchfish
- BBSRC [BB/H008780/1, BB/D01347X/1] Funding Source: UKRI
- MRC [G0900962, G0500950] Funding Source: UKRI
Ask authors/readers for more resources
Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.
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